Current Research

Research on Complex Regional Pain Syndrome is being done everyday so what is known and understood is always changing.  Here are some links to books and online publishings that we have found to be helpful.  This is not meant to be a comprehensive list but simply a guide to getting you started on your quest for additional information.

Provides a good overview of CRPS- what is is, how it’s treated, how it differs from adult CRPS including some related study findings

  • Published online April 29, 2016 by Pediatric Rheumatology Online Journal
  • Authored by Rotem Weissmann and Yosef Uziel, Pediatric Rheumatology Unit, Sackler School of Medicine, Tel Aviv University

MediFocus Guidebook Reflex Sympathetic Dystrophy

A comprehensive guide to symptoms, treatment, research and support

  • Last update:  January 29, 2017 by, Inc. (800)965-3002
  • Link for more information or to purchase online:

Complex Regional Pain Syndromes in Children and Adolescents

Covers some differences in CRPS between children, adolescents and adults

  • Published by Charles Berde, M.D., Ph.D. and Alyssa Lebel, M.D. in February 2005 issue of Anesthesiology, The Journal of the American Society of Anesthesiologists, Inc.

Compares treatment protocols and success between children and adults with CRPS

  • Written by Lorraine M. Taylor, MSN, CFNP in Topics in Advanced Practice Nursing eJournal in 2002

Provides an overview of CRPS symptoms, treatment and prognosis based on the research known at that time and offers some comparison to his observations at the Cleveland Clinic

  • Published by Michael Stanton-Hicks, MB, BS, Dr. Medical, FRCA, ABPM
  • Pain Medicine 2010; 11: 1216-1223

Discusses studies of CRPS patients including clinical presentation, clinical course, treatments, and outcomes.

  • Points out significant time to diagnose was common (about 3 months)
  • Concludes that treatment must be multifaceted (intense physical therapy, cognitive behavioral therapy, physio therapy, and medications to control pain)
  • Published in the Journal of Pediatric Orthopedics in July/August 2007

Blog discussing how to get the best medical care for CRPS

  • Published online in February 2009 by Oxford Journals
  • Discusses the musculoskeletal pain and other symptoms of CRPS and how to best manage

Discusses a study of twelve CRPS patients from the Pediatric Pain and Rehabilitation Center at Boston Children’s Hospital at Waltham, MA

  • Study found that CRPS alters brain networks differently in children as compared to adults and suggests that this information might be used to determine treatments
  • Suggests that intensive therapies can reverse some of these changes but not all of them

Q&A with Dr. Michael Stanton-Hicks

  • a board certified physician in pain management and anesthesiology and
  • pain consultant with the Cleveland Clinic’s Department of Pain Management and in the Center for Neurological Restoration.
  • He specializes in Complex Regional Pain Syndrome among others.

A list of frequently asked questions about coping with CRPS


Neridronate as a Possible Treatment/Cure for CRPS

Looks at a new drug/treatment therapy being tested in Italy using Neridronate intravenously as a possible cure of CRPS

Discusses clinical trials of the drug Neridronate as a cure for CRPS in the US

Focuses on the evidence/effectiveness Neridronate has on the treatment of CRPS type I in studies done up to the publication of this article in April 2013